学术讲座【Detection of Singlet Oxygen Phosphorescence – Prospects and Limits】
发布时间: 2017-07-05 浏览次数: 387

时间:2017年7月6日(周四)下午16:00-17:00

地点:仓山校区光电与信息工程学院四层学术报告厅

主讲:德国柏林洪堡大学,Steffen Hackbarth博士

主办:光电与信息工程学院、医学光电科学与技术教育部重点实验室、福建省光子技术重点实验室、福建省光电传感应用工程技术研究中心

专家概况:Dr. Steffen Hackbarth got his diploma in physics in 1995 from Humboldt University Berlin, where he also finished his PhD in 2000 in the Photobiophysics Group of Prof. R?der. Ever since then his work is focused on singlet oxygen and its detection. Finally, he became head of the singlet oxygen lab. Since 2008 the Berlin lab is the worldwide reference when it comes to the detection of singlet oxygen phosphorescence. Together with his colleague, Jan Schlothauer, he was awarded the Innovation Award 1st price individual researcher by SPIE Europe in 2012 for the development of a table-top detection system for singlet oxygen. They were the first to observe intracellular quencher consumption during a PDT treatment in cell suspensions and identify singlet oxygen diffusion effects in heterogeneous systems. A major focus of his work is on technical improvements for in vivo detection of singlet oxygen generation of systemically applied photosensitizers as well as the analysis of the detected kinetics thereof.

报告摘要:Singlet Oxygen (1O2), the first electronically excited form of oxygen, is the main mediator of Photodynamic Therapy or Photodynamic Inactivation of Multi-Resistant Bacteria. It can be generated by interaction of an excited photosensitizer and molecular oxygen. This species has a tiny, yet characteristic phosphorescence in the near infrared. For many years, just the detection of this emission was used as benchmark for NIR detection systems. Especially in biological environment this detection faces many limitations. Nevertheless, the desire and necessity of direct observation of 1O2 grew. In this context, the determination of the luminescence kinetics is of special importance. Within the kinetics, plenty of information is encoded, like the sub-microscopic localization of the PS in heterogeneous environment or the interaction of the 1O2 with local quenchers. The presented work reflects the efforts of the Berlin Photobiophysics Group to technically improve the detection as well as develop better means to analyze the gained kinetics.

 

 
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